Title:Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules
VOLUME: 21 ISSUE: 2
Author(s):Shubham Khot, Pratibha B. Auti* and Samrat A. Khedkar
Affiliation:Department of Pharmaceutical Chemistry, STES’s Sinhgad Institute of Pharmacy, Narhe, Pune-41, Maharashtra, Department of Pharmaceutical Chemistry, STES’s Sinhgad Institute of Pharmacy, Narhe, Pune-41, Maharashtra, Shikshan Prasarak Mandal’s College of Pharmacy, Akluj (Degree) Tal, Malshiras, Dist. Solapur 413101, Maharashtra
Keywords:Dihydropyridine, anticancer, anti-tubercular, ionizing radiation, anti-leishmanial, HIV-1.
Abstract:The current review discusses the different synthetic pathways for one of the most important
and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse
pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an
important role in several calcium-channel blockers. Moreover, it has been exploited for the treatment
of a variety of cardiovascular diseases due to its potential antihypertensive, anti-angina, vasodilator,
and cardiac depressant activities. Furthermore, it also shows antibacterial, anticancer, anti-leishmanial,
anticoagulant, anticonvulsant, anti-tubercular, antioxidant, antiulcer, and neuroprotective properties.
Several reports have demonstrated dihydropyridine derivatives as a potentiator of cystic fibrosis transmembrane
conductance regulator protein, potent antimalarial agent and HIV-1 protease inhibitor.
Herein, we have briefly reviewed different novel chemistry and the synthesis of 1,4-dihydropyridine.
