Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

Author(s): Shubham Khot, Pratibha B. Auti*, Samrat A. Khedkar

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 2 , 2021

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Graphical Abstract:


The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover, it has been exploited for the treatment of a variety of cardiovascular diseases due to its potential antihypertensive, anti-angina, vasodilator, and cardiac depressant activities. Furthermore, it also shows antibacterial, anticancer, anti-leishmanial, anticoagulant, anticonvulsant, anti-tubercular, antioxidant, antiulcer, and neuroprotective properties. Several reports have demonstrated dihydropyridine derivatives as a potentiator of cystic fibrosis transmembrane conductance regulator protein, potent antimalarial agent and HIV-1 protease inhibitor. Herein, we have briefly reviewed different novel chemistry and the synthesis of 1,4-dihydropyridine.

Keywords: Dihydropyridine, anticancer, anti-tubercular, ionizing radiation, anti-leishmanial, HIV-1.

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Article Details

Year: 2021
Published on: 09 February, 2021
Page: [135 - 149]
Pages: 15
DOI: 10.2174/1389557520666200807130215
Price: $65

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PDF: 17