Background: Dental professionals have so many opportunities to use injection needles
and sharp instruments during dental treatment that they face an increased risk of needlestick injuries.
This retrospective study reports the utilization and clinical outcomes of occupational post-exposure
prophylaxis (PEP) with anti-retroviral agents after being potentially exposed to HIV at the
dental departments of Hiroshima University Hospital.
Objective: This study reports the utilization and clinical outcomes of occupational post-exposure
prophylaxis (PEP) with antiretroviral agents after being potentially exposed to HIV at dental departments
of Hiroshima University Hospital.
Methods: Data on the clinical status of HIV-infected source patients and information on HIV-exposed
dental professionals from 2007 to 2018 were collected.
Results: Five dentists with an average experience of 5.6 years (1-15 years) were exposed. The averaged
CD4-positive cell number and HIV-RNA load were 1176 (768-1898) /μl and less than 20
copies/ml, respectively, in all the patients. Two of the five HIV exposed dentists received PEP.
Three months after the exposures, all of their results were negative in HIV antibody/antigen tests.
Conclusion: ; These data might support the concept of “undetectable equals untransmittable”, although
HIV exposure in this study was not through sexual transmission.
Keywords: HIV, U=U, occupational exposures, post-exposure prophylaxis, needlestick injury, dental treatment.
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