Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal
chemistry. Many marketed drugs and natural products containing benzimidazole scaffolds exert great influence in fighting
various diseases, such as hypertension, peptic ulcers, parasitic infections, and cancer. In this review, we introduce the
pharmacological applications of some marketed drugs and lead compounds with a focus on anticancer agents, reporting the
corresponding data to show the biological activities at their targets. The publications in this review encompass those from
2014 to 2019.
Keywords: Benzimidazole, privileged scaffold, anti-cancer, pharmacological applications, drug discovery.
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