Objective: The present investigation was aimed to isolate, characterize and establish a natural
polymer obtained from partially ripe and fresh fruits of Dillenia indica and its utility to deliver losartan
potassium in a sustained manner from microspheric macromolecular dosage form.
Methods: All the microspheres were prepared by ionotropic gelation technique and investigated for various
physico-chemical parameters along with in-vitro drug release studies to optimize the concentration
of algino-Dillenia polymeric blend required to develop twice daily sustained release dosage form of
Results: The functional characteristic studies and rheological behavior analysis suggested that extracted
polysaccharide can be used as a viscosity modifying agent as well as sustain release ingredient. All the
microsphere formulations exhibited excellent mucoadhesion properties and site-specific drug release.
In-vitro studies revealed that the optimum concentration of algino-Dillenia polymeric blend is suitable
to deliver losartan potassium in a sustained manner for a prolonged period of time. SEM study revealed
that the microspheres were spherical in shape with a smooth outer surface having small cracks. XRD
and DSC studies revealed that losartan potassium is present as an amorphous form in the prepared optimized
Conclusion: Thus, the present studies demonstrated that Dillenia fruit mucilage has an interesting rheological
behavior which may be used as a viscosity modifying agent and exhibit promising properties of
a sustained release dosage form to deliver losartan potassium from its microspheric dosage form.