Objective: The objective of this study was to evaluate the suitability of ternary mixture of smart polymers
comprised of Eudragit®E100, Eudragit®L100, and sodium alginate to serve as a carrier for sustained drug release for weakly
basic drugs. The model drug chosen in this part of the study is Metronidazole.
Methods: Matrix tablets formulations were
prepared by either direct compression or by wet granulation. Dissolution studies were conducted using USP XXΠ rotating
paddle apparatus in three different consecutive stages (pH 1.2, 4.8 and 6.8). Tablets made of low to intermediate proportions
of sodium alginate and an approximately equal proportions of Eudragit®E100 and Eudragit®L100 were found to have
significant modification of drug release rates.
Result: Thus, indicating a potential for controlling the drug release for 12
hours depending on polymers ratios in the formulation. The ratio of sodium alginate to total Eudragit® polymers and the
ratio of Eudragit®E100 to Eudragit®L100 within the ternary polymeric composition were found critical in determining the
controlled release performance.
Conclusion: Results of swelling studies were in agreement with the dissolution behaviors of
the tablets. The findings suggest the significance of the ternary polymeric compositions in controlling the release of weakly