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Review Article

Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery

Author(s): Shriya Agarwal, Vinayak Agarwal, Mugdha Agarwal and Manisha Singh*

Volume 20, Issue 3, 2020

Page: [195 - 206] Pages: 12

DOI: 10.2174/1566523220999200731011702

Price: $65

Abstract

In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

Keywords: Extracellular vesicles (EVs), viral vectors, genome, microRNA (miRNA), short hairpin RNA (shRNA), immunogenicity.

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Graphical Abstract

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