Aim and Objective: According to the literature survey, pyrazole is a unique template that is associated
with several biological activities. This article highlighted the research work of many researchers reported in the
literature for synthesis and different pharmacological activities of the pyrazole nucleus. In the present work, pyrazol-
3-one 1 was reacted with cyanoacetic acid hydrazide and elemental sulfur to afford the corresponding
thieno[3,2-c]pyrazol-6-carbohydrazide 3 derivatives. The latter compound reacted with some electrophilic reagents
such as DMF-DMA, triethylorthoformate, arylidenemalononitriles and chalcones under neat conditions to
give substituted oxadiazole and pyrazole, respectively. The treatment of compound 3 with active methylene reagents
such as acetylacetone, diethylmalonate, ethyl acetoacetate and ethyl cyanoacetate under suitable conditions
afforded pyrazole derivatives 10, 11, 13, and 15, respectively. Novel pyrazolothienopyrimidine 27 and 30 were
prepared from precursor 26 with carbon disulfide and triethylorthoformate, respectively. The chemical structures
of the newly synthesized compounds were established by elemental and spectral analyses including IR, and 1HNMR
in addition to 13C-NMR and mass spectra.
Materials and Methods: A novel substituted pyrazole, pyrimidine and pyrazolothienopyrimidine were obtained
via Gewald synthesis of thiophene and fused thiophene and Mannich reactions of 5-amino-3-phenyl-1Hthieno[
Results and Discussion: A series of some newly azoles and azines were prepared via reaction of thieno[3,2-
c]pyrazol-6-carbohydrazide derivative 3 as starting material with some electrophilic and nucleophilic reagents.
The structures of target compounds were established by elemental analyses and spectral data.
Conclusion: Pyrazole is a unique template that is associated with several biological activities. This article highlighted
the research work of many researchers reported in the literature for synthesis and different pharmacological
activities of the pyrazole nucleus. In the current investigation, we have developed new and efficient methods
for the synthesis of thieno[3,2-c]pyrazol-6-carbohydrazide derivatives. In addition, we have explored the preparative
potential of these substances as intermediates for the synthesis of substituted pyrazoles and fused pyrazoles