Background: SARS-CoV-2 causes COVID19 disease where there are no suitable drugs
Objective: The objective of the work is to repurpose the drugs prescribed for SARS-CoV as the
drugs for the control of SARS-CoV-2.
Methods: In this work, we have used homology searches and docking methods for understanding
the mechanism of the drugs prescribed for the control of SARS-CoV on SARS-CoV-2.
Results: In our analysis, we found that the drugs Benzyl (2-Oxopropyl)carbamate, 2-[(2,4-Dichloro-
5-methyl phenyl)sulfonyl]-1,3-dinitro-5-(trifluoromethyl)benzene, S-[5-(Trifluoromethyl)-4H-1,2,4-
triazol-3-YL] 5-(phenylethynyl)furan-2-carbothioate, 4-(Dimethylamino)benzoic acid, which are
capable of inhibition of the activity of 3CLPro and prevent the progression of SARS-CoV.
Conclusion: In this letter, we describe the findings of the protein ligand interactions between 3CLPro
of SARS-CoV, SARS-CoV-2 with Benzyl (2-oxopropyl) carbamate.