Drug Re-purposing from SARS-CoV Led the Identification of Potential Candidate Drug Target and Alternate Drug Molecules Against SARSCoV- 2

Author(s): PV Parvati Sai Arun*, Razak Hussain, Yusuf Akhter, Mandava Venkata Basaveswara Rao, Perugu Shyam, Sailu Yellaboina

Journal Name: Letters in Drug Design & Discovery

Volume 17 , Issue 10 , 2020


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Abstract:

Background: SARS-CoV-2 causes COVID19 disease where there are no suitable drugs available.

Objective: The objective of the work is to repurpose the drugs prescribed for SARS-CoV as the drugs for the control of SARS-CoV-2.

Methods: In this work, we have used homology searches and docking methods for understanding the mechanism of the drugs prescribed for the control of SARS-CoV on SARS-CoV-2.

Results: In our analysis, we found that the drugs Benzyl (2-Oxopropyl)carbamate, 2-[(2,4-Dichloro- 5-methyl phenyl)sulfonyl]-1,3-dinitro-5-(trifluoromethyl)benzene, S-[5-(Trifluoromethyl)-4H-1,2,4- triazol-3-YL] 5-(phenylethynyl)furan-2-carbothioate, 4-(Dimethylamino)benzoic acid, which are capable of inhibition of the activity of 3CLPro and prevent the progression of SARS-CoV.

Conclusion: In this letter, we describe the findings of the protein ligand interactions between 3CLPro of SARS-CoV, SARS-CoV-2 with Benzyl (2-oxopropyl) carbamate.

Keywords: Drugs, repurposing, SARS-CoV, SARS-CoV-2, 3CLpro, Benzyl(2-oxopropyl) carbamate.

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Article Details

VOLUME: 17
ISSUE: 10
Year: 2020
Published on: 11 October, 2020
Page: [1325 - 1327]
Pages: 3
DOI: 10.2174/1570180817999200730190600

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