The central dogma of molecular biology, has remained a cornerstone of classical molecular
biology. However, serendipitously discovered microRNAs (miRNAs) in nematodes paradigmatically
shifted our current knowledge of the intricate mechanisms during transitions from transcription
to translation. Thediscovery of miRNA captured considerable attention and appreciation, and
we had witnessed an explosion in the field of non-coding RNAs. Ground-breaking discoveries in
the field of non-coding RNAs have helped in better characterization of microRNAs and long noncoding
RNAs (LncRNAs). There is an ever-increasing list of miRNA targets that are regulated by
MALAT1 to stimulate or repress the expression of target genes. However, in this review, our main
focus is to summarize mechanistic insights on MALAT1-mediated regulation of oncogenic signaling
pathways. We have discussed how MALAT1 modulated TGF/SMAD and Hippo pathways in
various cancers. We have also comprehensively summarized how JAK/STAT and Wnt/β-catenin
pathways stimulated MALAT1 expression and consequentially how MALAT1 potentiated these
signaling cascades to promote cancer. MALAT1 research has undergone substantial broadening.
However, there is still a need to identify additional mechanisms. MALAT1 is involved in the multi-
-layered regulation of multiple transduction cascades, and detailed analysis of different pathways
will be advantageous in getting a step closer to individualized medicine.
Keywords: LncRNA, cancer, apoptosis, signaling, cascades, miRNAs.
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