Background: While iodine-enhanced computed tomography has been studied, detailed
information on gadolinium-enhanced magnetic resonance imaging has not been reported.
Objective: We evaluated the effects of different gadolinium contrast agent (Gd-CA) factors on the
enhancement of aortic magnetic resonance angiography (MRA) using computer simulation.
Methods: We developed computer-simulation software that combines pharmacokinetic models and
tables; it converts the blood concentration of particular Gd-CAs into the signal intensity (SI). We simulated
aortic time-intensity curves (TIC) in our MRA study and compared the effect of the Gd--
CA volume, injection rate, and of different Gd-CAs on the TIC.
Results: An increase in the Gd-CA volume from 14.0 to 28.0 ml increased maximal aortic intensity
1.11 times. Changing the injection rate from 1.0 to 2.8 ml/s increased it 1.10 times. The maximal
SI of gadoterate-meglumine and gadobutrol was 1.03 and 1.01 times, respectively, that of gadoteridol.
Conclusion: In our computer-simulated MRA study, different Gd-CA factors resulted in no significant
difference in the maximal aortic SI.