Background: The treatment of infection caused by pathogenic bacteria becomes one of the
serious concerns globally. The failure in the treatment was found due to the exhibition of multiple resistance
mechanisms against the antimicrobial agents. The emergence of resistant bacterial species has
also been observed due to prolong treatment using conventional antibiotics. To combat these problems,
several alternative strategies have been employed using biological and chemically synthesized compounds
as antibacterial agents. Marine organisms are considered as one of the potential sources for the
isolation of bioactive compounds due to the easily available, cost-effective, and eco-friendly.
Methods: The online search methodology was adapted for the collection of information related to the
antimicrobial properties of marine-derived compounds. These compound has been isolated and purified
by different purification techniques, and their structure also characterized. Furthermore, the antibacterial
activities have been reported by using broth microdilution as well as disc diffusion assays.
Results: The present review paper describes the antimicrobial effect of diverse secondary metabolites
which are isolated and purified from the different marine organisms. The structural elucidation of each
secondary metabolite has also been done in the present paper, which will help for the in silico designing
of the novel and potent antimicrobial compounds.
Conclusion: A thorough literature search has been made and summarizes the list of antimicrobial
compounds that are isolated from both prokaryotic and eukaryotic marine organisms. The information
obtained from the present paper will be helpful for the application of marine compounds as antimicrobial
agents against different antibiotic-resistant human pathogenic bacteria.