HIV-Tuberculous Meningitis Co-Infection: A Systematic Review and Meta-Analysis

Author(s): Ali Purmohamad, Taher Azimi, Mohammad J. Nasiri, Mehdi Goudarzi, Moein Zangiabadian, Hamid Sedighian, Abbas A.I. Fooladi*

Journal Name: Current Pharmaceutical Biotechnology

Volume 22 , Issue 7 , 2021

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Graphical Abstract:


Human Immunodeficiency Virus (HIV)-infected persons are at a higher risk of developing Tuberculous Meningitis (TBM). We aimed to estimate the prevalence of TBM-HIV co-infection. We systematically searched Pubmed/Medline, Embase and Cochrane library databases from January 1, 2000, to January 31, 2017, to find relevant studies. We employed the random-effects meta-analysis model to estimate the pooled prevalence of TBM-HIV co-infection. Twenty-six eligible studies showed the prevalence of HIV in TBM patients. In the pooled analyses, the prevalence of HIV was 30% (95% CI: 12-47) in patients with confirmed TBM, and 12.1% (95% CI: 7.3-19.2) in patients with suspected TBM. This study shows a high prevalence of TBM-HIV co-infection. Establishing proper diagnostic criteria and preventive measures for TBM infections could assist in the prevention and management of TBM infection, particularly TBM-HIV co-infection.

Keywords: Meta-analysis, HIV, meningitis, Mycobacterium tuberculosis, TBM, prevention.

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Article Details

Year: 2021
Published on: 07 June, 2021
Page: [960 - 968]
Pages: 9
DOI: 10.2174/1389201021666200730143906
Price: $65

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