Ascidians (tunicates) are widely recognized as one of the most prolific producers of bioactive
natural products in the marine environment. This present study reviewed the chemical diversity
of marine ascidians from the Aplidium genus and their pharmacological applications since Jan 2005.
The resources of this genus from China Seas, including the changes of their names in the family Polydinidae
were also summarized in this paper. In addition, a concise outlook on their chemical and
pharmaceutical investigation is made to support further development.
Keywords: Aplidium, bioactivities, marine environment, natural products, polydinidae, secondary metabolites.
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