Background: Acne vulgaris a chronic disease which is caused by blockage of the
sebaceous gland is commonly seen in almost every human being at some point in their lives.
There are 20-25% chances of progression of acne to severe cases, which leads to permanent
scarring that results in psychological problems like depression, social isolation, lowered
self-esteem, and lowered self-confidence.
Objective: Though several conventional treatments are available in the market but still there
are various adverse effects associated with topical anti-acne agents due to which it lacks patient
compatibility. The present study is undertaken to find out the major shortcoming; why
the current therapies do not give the desired therapeutic results.
Conclusion: Novel drug delivery strategies can play a crucial role in the enhancement of
topical delivery of anti-acne agents by escalating their dermal localization and reducing
their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia
etc. have clinical evidence regarding the effective management of acne. The current inclination
towards nanotechnology is considerable due to several changes in the pharmaceutical
research area. To secure the research work in different pharmaceutical fields, patents are
filed against various agents like Galderma Research & Development have filed patents for
adapalene and benzoyl peroxide for the management of acne vulgaris. The current review
highlights the potential of various novel drug delivery approaches like liposomes, niosomes,
ethosomes, transfersomes etc. in enhancing the topical delivery of anti-acne agents.