The Progress of the Anticancer Agents Related to the Microtubules Target

Author(s): Olagoke Zacchaeus Olatunde, Jianping Yong*, Canzhong Lu*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 20 , 2020

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Abstract:

Anticancer drugs based on the microtubules target are potent mitotic spindle poison agents, which interact directly with the microtubules, and were classified as microtubule-stabilizing agents and microtubule-destabilizing agents. Researchers have worked tremendously towards the improvements of anticancer drugs, in terms of improving the efficacy, solubility and reducing the side effects, which brought about advancement in chemotherapy. In this review, we focused on describing the discovery, structures and functions of the microtubules as well as the progress of anticancer agents related to the microtubules, which will provide adequate references for researchers.

Keywords: Microtubules, structures, functions, mechanism, target, anticancer agents.

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Article Details

VOLUME: 20
ISSUE: 20
Year: 2020
Published on: 14 January, 2021
Page: [2165 - 2192]
Pages: 28
DOI: 10.2174/1389557520666200729162510
Price: $65

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