The treatment of cancer has always been a major problem in the world. Some cancers cannot
be treated with surgery, but only with cancer drugs. Among many cancer drugs, small molecule
inhibitors play an irreplaceable role. HER2 is one of the HER families, and the development of HER2
inhibitors has made a huge contribution to the treatment of cancer. Some HER2 inhibitors are already
on the market, and some HER2 inhibitors are undergoing clinical research. The design, synthesis and
development of new HER2 inhibitors targeting different targets are also ongoing, and some are even
under clinical research. The HER2 inhibitors that are on the market have developed resistance, which
brings great challenges to the HER2 inhibitor development in the future. This article reviews the
development and challenges of the discovery of HER2 inhibitors.
Keywords: Cancer, HER2, challenges, inhibitors, drug resistance, discovery.
Rights & PermissionsPrintExport