Title:Current Trends on Hemopoietic Stem Cells
VOLUME: 16 ISSUE: 2
Author(s):Chinwe Okeke*, Ufele Silas, Chinedu Okeke and Chiedozie Chikwendu
Affiliation:Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria Nsukka, Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria Nsukka, Haematology Department, College of Medicine,University of Abuja, Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria Nsukka
Keywords:Stem cells, haemopoiesis, transplantation, blood, haemopoietic, differentiation.
Abstract:Advances in single-cell technology and genetic mouse models have resulted in the identification
of new types of hemopoietic stem cells (HSC), resulting in baffling observations, suggesting a
reconsideration of the long-held notion that all hematopoietic cells in the adult are derived from HSCs.
The existence of long-lived HSC-independent hematopoiesis has led to the conclusion that despite the
single hierarchical differentiation route that generates functional blood types, other differentiation
routes exist in-vivo. Heterogeneity in the HSC population and the evolving knowledge around HSC has
translated to it’s improved application as a therapeutic tool for various blood disorders. The reprogramming
of non-hematopoietic somatic and mature blood cells to pluripotency with their subsequent
differentiation into hematopoietic stem cells/progenitor cells and the introduction of new generation
sequencing holds the potential for the resolution of ambiguities involved in HSC bone marrow transplantation.
There is a change in the paradigm for HSC transplantation donor selection. Donor choice
favors haploidentical HCT than cord blood. This review provides a general overview of the current
events around hemopoietic stem cells, with emphasis on the rising trend of HSC transplantation, especially
haploidentical stem cell transplantation.
