Favipiravir in the Spotlight: In Search of Treatment Against COVID-19

Title:Favipiravir in the Spotlight: In Search of Treatment Against COVID-19

Volume: 2 Issue: 1

Author(s): Victor Facchinetti and Marcus Vinícius Nora de Souza*

Affiliation:

• Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos, Rua Sizenando Nabuco 100, Rio de Janeiro, RJ,Brazil

Keywords: Coronavirus, COVID-19, favipiravir, synthesis, mechanism of action, pharmacology

Abstract:

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), sometimes referred to as the novel coronavirus (2019-nCoV), is currently a worldwide threat to public health. According to the Johns Hopkins University monitor (available at, coronavirus.jhu.edu/map), there have been more than 10 million reported cases of coronavirus 2019 disease (COVID-19) and 500,000 deaths as of June 29, 2020, deeming urgent the identification of a drug candidate and treatment regimen.

Objective: This work aims to compile the current knowledge available on this drug, including its background, approved uses, some synthetic methods, the primary pharmacological aspects, the results against COVID-19 reported so far, and ongoing clinical trials against COVID-19.

Methods: We reviewed relevant press releases, scientific articles, and official documents to compile information about Favipiravir.

Results: We highlight, in a clear and concise form, not only the published and ongoing clinical trials on the use of Favipiravir against COVID-19 but also compile some relevant synthetic and pharmacological information available about this drug.

Conclusion: The Antiviral Favipiravir has shown interesting preliminary results, but it seems too early to recommend a treatment protocol for COVID-19 based on this drug. Robust clinical trials that will provide less biased data on its efficacy and safety are being pushed forward by FUJIFILM Corporation and by research groups around the globe.

Cite this article as:

Facchinetti Victor and de Souza Marcus Vinícius Nora*, Favipiravir in the Spotlight: In Search of Treatment Against COVID-19, Coronaviruses 2021; 2 (1) : e160223184322 . https://dx.doi.org/10.2174/2666796701999200729155347