Myxofibrosarcoma: Clinical and Prognostic Value of MRI Features

Author(s): Paolo Spinnato*, Andrea Sambri, Tomohiro Fujiwara, Luca Ceccarelli, Roberta Clinca, Manuel R. Medellin, Massimiliano De Paolis, Davide M. Donati, Giuseppe Bianchi

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Volume 17 , Issue 2 , 2021

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Graphical Abstract:


Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma, which plays a key role in the preoperative setting of these patients. MRI features associated with the high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement and presence of an infiltrative pattern (“tail sign”). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful in stratifying the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features.

Keywords: Magnetic resonance imaging, sarcoma, soft tissue neoplasm, neoplasm invasivenes, prognosis, local neoplasm recurrence.

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Article Details

Year: 2021
Published on: 15 March, 2021
Page: [217 - 224]
Pages: 8
DOI: 10.2174/1573405616999200729152135
Price: $65

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