Title:A Case of Acute Generalized Exanthematous Pustulosis by Cefixime with Oral Mucosal Involvement
VOLUME: 15 ISSUE: 3
Author(s):Ramanachary Namoju*, Mohammed Ismail, Vinay Kumar Golla, Tejaswini Bamini, Thanmaya Lakshmi Akarapu and Deepika Baloju
Affiliation:Department of Pharmacology Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana 500075, Department of Pharmacology Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana 500075, Department of Pharmacology Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana 500075, Department of Pharmacology Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana 500075, Department of Pharmacology Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana 500075, Patient Safety Pharmacovigilance Associate, Adverse Drug Reaction Monitoring Centre – Pharmacovigilance Program of India, Department of Pharmacology, Bhaskar Medical College, Hyderabad, Telangana 50007
Keywords:Cefixime, acute generalized exanthematous pustulosis, mucous membrane involvement, non-follicular pustules,
severe cutaneous adverse reaction, erythematous eruption.
Abstract:Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse
reaction characterized by the development of numerous sterile and non-follicular pustules on an erythematous
base with no or minimal mucous membrane involvement associated with fever and leucocytosis.
Cefixime is a cephalosporin-type beta-lactam antibiotic commonly used for the management
of several infections. The Cefixime-induced AGEP cases are known to be rare. Here, we present
the case report of a 26-year old female who developed Cefixime-induced AGEP with mucosal
membrane involvement. To the best of our knowledge, this is the first case to report the mucosal
membrane involvement in Cefixime-induced AGEP. We are presenting this case report to draw the
attention on the existence and plethora of symptoms of Cefixime-induced AGEP hoping that the
clinicians will reckon these in their differential diagnosis and implement the appropriate management
strategies for this rare adverse event in their clinical practice.
