Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse
reaction characterized by the development of numerous sterile and non-follicular pustules on an erythematous
base with no or minimal mucous membrane involvement associated with fever and leucocytosis.
Cefixime is a cephalosporin-type beta-lactam antibiotic commonly used for the management
of several infections. The Cefixime-induced AGEP cases are known to be rare. Here, we present
the case report of a 26-year old female who developed Cefixime-induced AGEP with mucosal
membrane involvement. To the best of our knowledge, this is the first case to report the mucosal
membrane involvement in Cefixime-induced AGEP. We are presenting this case report to draw the
attention on the existence and plethora of symptoms of Cefixime-induced AGEP hoping that the
clinicians will reckon these in their differential diagnosis and implement the appropriate management
strategies for this rare adverse event in their clinical practice.
Keywords: Cefixime, acute generalized exanthematous pustulosis, mucous membrane involvement, non-follicular pustules,
severe cutaneous adverse reaction, erythematous eruption.
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