Title:Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic, and Immune Disorders
VOLUME: 20
Author(s):Ciro Gargiulo Isacco, Andrea Ballini *, Danila De Vito, Kieu Cao Diem Nguyen, Stefania Cantore, Lucrezia Bottalico, Lucio Quagliuolo, Mariarosaria Boccellino, Marina Di Domenico, Luigi Santacroce, Roberto Arrigoni, Gianna Dipalma and Francesco Inchingolo
Affiliation:Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Department of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario “Ernesto Quagliariello”, University of Bari "Aldo Moro", 70125 Bari, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70121 Bari, Human Stem Cell Research Center-HSC, Ho Chi Minh City, Vietnam; f Sorriso & Benessere Ricerca e Clinica S.r.l., 70121 Bari, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, PolyPheno S.r.l. Academic Spin Off, University of Bari "Aldo Moro", 74123 Taranto, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Jonian Department, University of Bari "Aldo Moro", 70121 Bari, CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70125 Bari, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari
Keywords: periodontal disease, oral dysbiosis, gut dysbiosis, central nervous system (CNS) diseases; probiotics, macrophages.
Abstract:The current treatment and prevention of oral disorders follow a very sectoral control and procedures considering
mouth and its structures as system completely independent from the rest of the body. The main therapeutic approach is
carried out on just to keep the levels of oral bacteria and hygiene in an acceptable range compatible with one-way vision of
oral-mouth health completely separated from a systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively
impact on the diagnosis of more complex systemic disease and its progression. Dysbiosis is consequence of oral and gut
microbiota unbalance with consequences, as reported in current literature, in cardio vascular disease, diabetes mellitus,
rheumatoid arthritis, and Alzheimer’s disease. Likewise, there is the need to highlight and develop a novel philosophical
approach in the treatments for oral diseases that will necessarily involve non-conventional approaches.
