Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic, and Immune Disorders

(E-pub Ahead of Print)

Author(s): Ciro Gargiulo Isacco, Andrea Ballini*, Danila De Vito, Kieu Cao Diem Nguyen, Stefania Cantore, Lucrezia Bottalico, Lucio Quagliuolo, Mariarosaria Boccellino, Marina Di Domenico, Luigi Santacroce, Roberto Arrigoni, Gianna Dipalma, Francesco Inchingolo

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Become EABM
Become Reviewer


The current treatment and prevention of oral disorders follow a very sectoral control and procedures considering mouth and its structures as system completely independent from the rest of the body. The main therapeutic approach is carried out on just to keep the levels of oral bacteria and hygiene in an acceptable range compatible with one-way vision of oral-mouth health completely separated from a systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact on the diagnosis of more complex systemic disease and its progression. Dysbiosis is consequence of oral and gut microbiota unbalance with consequences, as reported in current literature, in cardio vascular disease, diabetes mellitus, rheumatoid arthritis, and Alzheimer’s disease. Likewise, there is the need to highlight and develop a novel philosophical approach in the treatments for oral diseases that will necessarily involve non-conventional approaches.

Keywords: periodontal disease, oral dysbiosis, gut dysbiosis, central nervous system (CNS) diseases; probiotics, macrophages.

Rights & PermissionsPrintExport Cite as

Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1871530320666200729142504
Price: $95

Article Metrics

PDF: 37