Visible Light Assisted Synthesis of 5-Aryl-1,2,4-thiazolidine-3-thiones Under Catalyst-free Condition

Author(s): Amol Khandebharad*, Swapnil Sarda, Pravin Kulkarni, Brijmohan Agrawal

Journal Name: Current Green Chemistry

Volume 7 , Issue 3 , 2020

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Graphical Abstract:


Light energy can be considered as an ideal eco-friendly source of energy for green chemistry. This perspective was used to synthesize 5-aryl-1,2,4-thiazolidine-3-thiones derivative as a quick, efficient and highly improved protocol. The present method developed an energy competent and integrated technique by one-pot condensations of aromatic aldehyde and thiosemicarbazide under the catalyst-free condition in aqueous-alcoholic media. The impact of light on reaction along with mechanical stirring provided a prominent yield of the product. The mild reaction conditions, short reaction time and easy workup procedure, avoidance of heavy metal catalyst and harsh reaction conditions make this protocol greener.

Keywords: Aromatic aldehyde, thiosemicarbazide, water: ethanol (1:1), visible light, thio-triazole derivatives, green chemistry.

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Article Details

Year: 2020
Page: [326 - 333]
Pages: 8
DOI: 10.2174/2213346107999200729131533
Price: $25

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