This review aims to highlight urgent priorities for the computational biomechanics community in the
framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges
on the computational modelling of arterial tissues in health and disease are introduced and investigated, together
with in silico approaches for the analysis of drug-eluting stents that promote pharmacological-induced healing.
The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical
engineering models but are most likely instrumental for the onset and the progression of arterial diseases. An
interdisciplinary effort is thus encouraged for providing the tools for an effective in silico insight into medical
problems. An integrated mechano-chemo-biological perspective is believed to be a fundamental missing piece for
crossing the bridge between computational engineering and life sciences, and for bringing computational biomechanics
into medical research and clinical practice.
Keywords: Mechano-chemo-biological models, growth and remodelling, drug-eluting stents, arterial diseases, pharmacological-induced
healing, computational biomechanics.
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