Mechano-chemo-biological Computational Models for Arteries in Health, Disease and Healing: From Tissue Remodelling to Drug-eluting Devices

Author(s): Michele Marino*, Giuseppe Vairo, Peter Wriggers

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 16 , 2021


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Abstract:

This review aims to highlight urgent priorities for the computational biomechanics community in the framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges on the computational modelling of arterial tissues in health and disease are introduced and investigated, together with in silico approaches for the analysis of drug-eluting stents that promote pharmacological-induced healing. The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical engineering models but are most likely instrumental for the onset and the progression of arterial diseases. An interdisciplinary effort is thus encouraged for providing the tools for an effective in silico insight into medical problems. An integrated mechano-chemo-biological perspective is believed to be a fundamental missing piece for crossing the bridge between computational engineering and life sciences, and for bringing computational biomechanics into medical research and clinical practice.

Keywords: Mechano-chemo-biological models, growth and remodelling, drug-eluting stents, arterial diseases, pharmacological-induced healing, computational biomechanics.

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Article Details

VOLUME: 27
ISSUE: 16
Year: 2021
Published on: 28 July, 2020
Page: [1904 - 1917]
Pages: 14
DOI: 10.2174/1381612826666200728145752
Price: $65

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