Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections

Author(s): Ammara Riaz, Azhar Rasul*, Nazia Kanwal, Ghulam Hussain, Muhammad Ajmal Shah*, Iqra Sarfraz, Rubab Ishfaq, Rabia Batool, Fariha Rukhsar, Şevki Adem

Journal Name: Current Drug Metabolism

Volume 21 , Issue 14 , 2020

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Graphical Abstract:


Natural products, an infinite reserve of bioactive molecules, will continue to serve humans as an important source of therapeutic agents. Germacrone is a bioactive natural compound found in the traditional medicinal plants of family Zingiberaceae. This multifaceted chemical entity has become a point of focus during recent years due to its numerous pharmacological applications, e.g., anticancer, anti-inflammatory, antiviral, antioxidant, anti-adipogenic, anti-androgenic, antimicrobial, insecticidal, and neuroprotective. Germacrone is an effective inducer of cell cycle arrest and apoptosis in various cancers (breast, brain, liver, skin, prostate, gastric, and esophageal) via modulation of different cell signaling molecules and pathways involved in cancer proliferation. This is the first report highlighting the wide spectrum of pharmacological activities exhibited by germacrone. The reported data collected from various shreds of evidences recommend that this multifaceted compound could serve as a potential drug candidate in the near future.

Keywords: Germacrone, anticancer, antimicrobial, anti-inflammatory, anti-adipogenic, neuroprotective, anti-androgenic.

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Article Details

Year: 2020
Published on: 28 July, 2020
Page: [1079 - 1090]
Pages: 12
DOI: 10.2174/1389200221999200728144801
Price: $65

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