Background: Hepatitis C Virus (HCV) belongs to the Hepacivirus family. HCV has been
designated as a very dreadful virus as it can attack the liver, causing inflammation and even may lead
to cancer in chronic conditions. It was estimated that 71 million people around the world have chronic
HCV infection. World Health Organization (WHO) reported that about 399000 people died because of
chronic cirrhosis and liver cancer globally. In spite of the abundance of availability of drugs for the
treatment of HCV, however, the issue of drug resistance surpasses all the possibilities of therapeutic
management of HCV. Therefore, to address this issue of ‘drug-resistance’, various HCV targets were
explored to quest the evaluation of the mechanism of the disease progression.
Methods: An attempt has been made in the present study to explore the various targets of HCV involved
in the mechanism(s) of the disease initiation and progression and to focus on the mode of binding
of ligands, which are co-crystallized at the active cavity of different HCV targets.
Conclusion: The present study could predict some crucial features of these ligands, which possibly
interacted with various amino acid residues responsible for their biological activity and molecular signaling
pathway(s). Such binding mode may be considered as a template for the high throughput
screening and designing of active congeneric ligands to combat HCV.