Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives

Author(s): Wang Gong, Fei Wang, Yuqing He, Xin Zeng, Dunfang Zhang*, Qianming Chen

Journal Name: Current Stem Cell Research & Therapy

Volume 16 , Issue 2 , 2021


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Abstract:

Mesenchymal stem cell (MSC) therapy for clinical diseases associated with inflammation and tissue damage has become a progressive treatment strategy. MSCs have unique biological functions, such as homing, immune regulation, and differentiation capabilities, which provide the prerequisites for the treatment of clinical diseases. Oral diseases are often associated with abnormal immune regulation and epithelial tissue damage. In this review, we summarize previous studies that use MSC therapy to treat various oral inflammatory diseases, including oral ulceration, allergic diseases, chemo/radiotherapy-induced oral mucositis, periodontitis, osteonecrosis of the jaw, Sjögren's syndrome (SS), among other similar diseases. We highlight MSC treatment as a promising approach in the management of oral inflammatory diseases, and discuss the obstacles that remain and must be overcome for MSC treatment to thrive in the future.

Keywords: Mesenchymal Stem Cells (MSCs), Oral Diseases, Stem cell differentiation, Oral inflammation, Immune regulation, MSC Therapy.

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2021
Published on: 12 February, 2021
Page: [165 - 174]
Pages: 10
DOI: 10.2174/1574888X15666200726224132
Price: $65

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