Current Challenges and Implications of Proteogenomic Approaches in Prostate Cancer

Author(s): Nidhi Shukla, Narmadhaa Siva, Babita Malik, Prashanth Suravajhala*

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 22 , 2020

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Graphical Abstract:


In the recent past, next-generation sequencing (NGS) approaches have heralded the omics era. With NGS data burgeoning, there arose a need to disseminate the omic data better. Proteogenomics has been vividly used for characterising the functions of candidate genes and is applied in ascertaining various diseased phenotypes, including cancers. However, not much is known about the role and application of proteogenomics, especially Prostate Cancer (PCa). In this review, we outline the need for proteogenomic approaches, their applications and their role in PCa.

Keywords: Prostate Cancer, Next-Generation sequencing, Genomics, Proteomics, Proteogenomics, Transcriptomics, Phosphoproteomics.

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Year: 2020
Page: [1968 - 1980]
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DOI: 10.2174/1568026620666200722112450
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