Intestinal hyperpermeability is a complex metabolic process mediated by different pathways
in close relation to the gut microbiota. Previous studies suggested that the gut microbiota is involved
in different metabolic regulations, and its imbalance is associated with several metabolic diseases,
including obesity. It is well known that intestinal hyperpermeability is associated with dysbiosis,
and the combination of these two conditions can lead to an increase in the level of low-grade inflammation
in obese patients due to an increase in pro-inflammatory cytokine levels. Inflammatory
bowel syndrome often accompanies this condition causing an alteration of the intestinal mucosa and
thus reinforcing the dysbiosis and gut hyperpermeability. The onset of metabolic disorders depends on
violations of the integrity of the intestinal barrier as a result of increased intestinal permeability.
Chronic inflammation due to endotoxemia is responsible for the development of obesity. Metabolic
disorders are associated with dysregulation of the microbiota-gut-brain axis and with an altered composition
of gut flora. In this review, we will discuss the mechanisms that illustrate the relationship between
hyperpermeability, the composition of the gut microbiota, and obesity.
Keywords: Gut microbiota, intestinal hyperpermeability, obesity, gut inflammation, metabolic, metabolic regulation.
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