Common therapy of cancer, such as chemotherapy, has various side effects for the patients. In recent
studies, new therapeutic approaches in cancer treatment are adjuvant therapy, along with a reduction in side
effects of chemotherapy drugs. Treatment by herbal medicines may have some advantages over treatment with
single purified chemicals, also in terms of side effects, the use of plants in cancer treatment is a more secure
method. Citrus fruits are one of the most consumed natural products in the world due to the presence of various
metabolites and bioactive compounds, such as phenols, flavonoids and, carotenoids. Bioactive compounds of
citrus modulate signaling pathways and interact with signaling molecules such as apoptotic and cell cycle (P53,
P21, etc.) and thus have a wide range of pharmacological activities, including anti-inflammatory, anti-cancer
and oxidative stress. The findings discussed in this review strongly support their potential as anti-cancer agents.
Therefore, the purpose of this review was to examine the effects of active compounds in citrus as a therapy
agent in cancer treatment.