Breast cancer (BC) is the commonest cause of cancer deaths among Women. It is known to be
caused due to mutations in certain receptors, viz. estrogens or progesterones. The most frequently used conventional
treatment strategies against BC include chemotherapy, radiation therapy, and partial or entire mastectomy,
however, these strategies are often associated with multiple adverse effects, thus reducing patient compliance.
Advancement of nanotechnology in the medical application has been made to enhance the therapeutic
effectiveness with a significant reduction in the unintended side-effects associated with incorporated anticancer
drugs against cancer. The surface engineering technology of the nanocarriers is more pronounced in delivering
the therapeutics specifically to target cells. Consequently, folic acid, a small molecular ligand for the folate receptor
overexpressed cells, has shown immense response in treating BC cells. Folic acid conjugated nanocarriers
have shown remarkable efficiency in targeting overexpressed folate receptors on the surface of BC cells.
Binding of these target-specific folate-conjugated nanocarriers substantially improves the internalization of chemotherapeutics
in BC cells, without much exposing the other parts of the body. Simultaneously, these folate--
conjugated nanocarriers provide imaging for regular monitoring of targeted drug delivery systems and their responses
to an anticancer therapy. Therefore, this review demonstrates the potential of folate-conjugated nanotherapeutics
for the treatment and theranostic approaches against BC along with the significant challenges to anticancer
therapy, and the prospective insights into the clinical importance and effectiveness of folate conjugate