Title:Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases
VOLUME: 18
Author(s):Graziella dos Reis Franco, Scott Smid and Cláudio Viegas Jr.*
Affiliation:PeQuiM- Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37133- 840, Discipline of Pharmacology, Adelaide Medical School, The University of Adelaide, South Australia, 5000, PeQuiM- Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37133- 840
Keywords:Phytocannabinoids, Endocannabinoid System, Neurodegenerative Diseases, Cannabis sp., Cannabinoid Receptors.
Abstract:In the last few years research into Cannabis and its constituent phytocannabinoids has burgeoned, particularly in
the potential application of novel cannabis phytochemicals for the treatment of diverse illnesses related to neurodegeneration and dementia, including Alzheimer’s (AD), Parkinson’s (PD) and Huntington’s disease (HD). To date, these neurological diseases have mostly relied on symptomatological management. However, with an aging population globally, the search
for more efficient and disease-modifying treatments that could delay or mitigate disease progression is imperative. In this
context, this review aims to present a state of art in the research with cannabinoids and novel cannabinoid-based drug candidates that have been emerged as novel promising alternatives for drug development and innovation in the therapeutics of a
number of diseases, especially those related to CNS-disturbance and impairment.
