Title:Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases
VOLUME: 19 ISSUE: 4
Author(s):Graziella dos Reis Rosa Franco, Scott Smid and Cláudio Viegas *
Affiliation:PeQuiM-Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37133- 840, Discipline of Pharmacology, Adelaide Medical School, The University of Adelaide, South Australia, 5000, PeQuiM-Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37133- 840
Keywords:Phytocannabinoids, endocannabinoid system, neurodegenerative diseases, cannabis sp. cannabinoid receptors,
neurological disorders.
Abstract:In the last few years research into Cannabis and its constituent phytocannabinoids has
burgeoned, particularly in the potential application of novel cannabis phytochemicals for the treatment
of diverse illnesses related to neurodegeneration and dementia, including Alzheimer’s (AD),
Parkinson’s (PD) and Huntington’s disease (HD). To date, these neurological diseases have mostly
relied on symptomatological management. However, with an aging population globally, the search
for more efficient and disease-modifying treatments that could delay or mitigate disease progression
is imperative. In this context, this review aims to present state of the art in the research with cannabinoids
and novel cannabinoid-based drug candidates that have been emerged as novel promising
alternatives for drug development and innovation in the therapeutics of a number of diseases, especially
those related to CNS-disturbance and impairment.
