Tumor-Induced Metabolism and T Cells Located in Tumor Environment

Author(s): Sara Iranparast, Sanaz Tayebi, Fatemeh Ahmadpour, Bahman Yousefi*

Journal Name: Current Cancer Drug Targets

Volume 20 , Issue 10 , 2020


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Graphical Abstract:


Abstract:

Several subtypes of T cells are located in a tumor environment, each of which supplies their energy using different metabolic mechanisms. Since the cancer cells require high levels of glucose, the conditions of food poverty in the tumor environment can cause inactivation of immune cells, especially the T-effector cells, due to the need for glucose in the early stages of these cells activity. Different signaling pathways, such as PI3K-AKt-mTOR, MAPK, HIF-1α, etc., are activated or inactivated by the amount and type of energy source or oxygen levels that determine the fate of T cells in a cancerous environment. This review describes the metabolites in the tumor environment and their effects on the function of T cells. It also explains the signaling pathway of T cells in the tumor and normal conditions, due to the level of access to available metabolites and subtypes of T cells in the tumor environment.

Keywords: Cancer, t lymphocytes, metabolism, immunotherapy, immune evasion, cytokines.

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VOLUME: 20
ISSUE: 10
Year: 2020
Published on: 19 July, 2020
Page: [741 - 756]
Pages: 16
DOI: 10.2174/1568009620666200720010647
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