Role of Lactate Dehydrogenase in the Prediction of Severity in Pre- Eclampsia

Author(s): Feriha F. Khidri*, Fozia Shaikh, Imran-ul-Hassan Khowaja, Hina Riaz

Journal Name: Current Hypertension Reviews

Volume 16 , Issue 3 , 2020

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Graphical Abstract:


Background: Pre-eclampsia is a hypertensive pregnancy disorder accompanied by proteinuria. Serum Lactate Dehydrogenase (LDH) is a biochemical marker that reflects the severity and progression of pre-eclampsia.

Methods: A cross-sectional study was conducted at the Liaquat University of Medical and Health Sciences (LUMHS). One hundred pre-eclamptic women were enrolled and categorized into mild (n=30) and severe pre-eclamptic groups (n=70) to ascertain the function of LDH as a prognostic marker and to assess its association with severity and gestational age in pre-eclamptic women.

Results: The significant differences in mean concentrations of LDH between mild and severe preeclamptic women (p-value <0.0001) and early and late-onset pre-eclamptic women (p-value=0.049) were found. Significant differences were also found in the LDH range between mild and severe preeclamptic women presented with late-onset pre-eclampsia (p-value= 0.004). Statistically significant differences (p-value= 0.019) in the levels of LDH were found with systolic blood pressure and proteinuria (p-value= 0.048).

Conclusion: LDH is the prognostic marker representing the severity of pre-eclampsia. An increased level of LDH directs adequate monitoring and management; and by early detection of preeclampsia, serious consequences and complications may be prevented.

Keywords: Blood pressure, gestational age, LDH, proteinuria, pre-eclampsia, severity, hypertensive pregnancy disorder.

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Article Details

Year: 2020
Page: [223 - 228]
Pages: 6
DOI: 10.2174/1573402116666200720001032
Price: $65

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