Title:Transient Hepatotoxicity Induced by Vinblastine in a Young Girl with Chiasmatic Low Grade Glioma
VOLUME: 15 ISSUE: 3
Author(s):Niels E. Franke*, Geert Jan Blok, Marsha L. Voll and Antoinette Y.N. Schouten-van Meeteren
Affiliation:Princess Maxima Center for Pediatric Oncology, PO box 113, 3720 AC Bilthoven, Northwest Clinics, Department of Pediatrics, Wilhelminalaan 12, 1815 JD Alkmaar, Amsterdam UMC - Location AMC; PO box 22660; 1100 DD Amsterdam, Princess Maxima Center for Pediatric Oncology, PO box 113, 3720 AC Bilthoven
Keywords:Vinblastine, hepatotoxicity, CTCAE, low-grade glioma, infant, chiasmatic.
Abstract:
Background: Vinblastine (VBL) is a cytostatic drug frequently applied in children with
lymphoma and progressive low-grade glioma (LGG), with hematotoxicity as the main side effect.
Case Report: Here, the case of a 7-month-old girl with tumor progression of an LGG during standard
chemotherapy with carboplatin and vincristine, is presented. Switching to VBL led to a 20-30-
fold increase of transaminases (grade IV CTCAE 5.0), spontaneously resolving after the end of
treatment. The toxicity is possibly age-related since it did not re-occur at the restart of VBL at 4
years old. This finding might have consequences for toxicity screening in future protocols, especially
when including infants.
