Title:Therapeutic and Mechanistic Approaches of <i>Tridax Procumbens</i> Flavonoids for the Treatment of Osteoporosis
VOLUME: 21 ISSUE: 16
Author(s):Md. Abdul Alim Al-Bari*, Showna Hossain, Ujjal Mia and Md. Abdullah Al Mamun
Affiliation:Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet-3114
Keywords:TPFs, bone remodelling, osteoclast differentiation, osteoporosis, NFATc1, Bone Mineral Density (BMD).
Abstract:Homeostasis of bone is closely regulated by the balanced activities between the bone resorbing
activity of osteoclast cells and bone-forming ability of osteoblast cells. Multinucleated osteoclasts
degrade bone matrix and involve in the dynamic bone remodelling in coordination with osteoblasts.
Disruption of this regulatory balance between these cells or any imbalance in bone remodelling
caused by a higher rate of resorption over construction of bone results in a decrease of bone matrix including
bone mineral density (BMD). These osteoclast-dominant effects result in a higher risk of bone
crack and joint demolition in several bone-related diseases, including osteoporosis and rheumatoid arthritis
(RA). Tridax procumbens is a very interesting perennial plant and its secondary metabolites
called here T. procumbens flavonoids (TPFs) are well‐known phytochemical agents owing to various
therapeutic practices such as anti-inflammatory, anti-anaemic and anti-diabetic actions. This review
designed to focus the systematic convention concerning the medicinal property and mechanism of actions
of TPFs for the management of bone-related diseases. Based on the current literature, the review
offers evidence-based information of TPFs for basic researchers and clinicians for the prevention and
treatment of bone related diseases, including osteoporosis. It also emphasizes the medical significance
for more research to comprehend the cellular signalling pathways of TPFs for the regulation of bone
remodelling and discusses the possible promising ethnobotanical resource that can convey the preclinical
and clinical clues to develop the next generation therapeutic agents for the treatment of bonerelated
disorders.
