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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Review Article

An Insight into Unani Hypoglycemic Drugs and Their Mechanism of Action

Author(s): Mohammad Fazil, Sadia Nikhat and Imran Ali*

Volume 24, Issue 2, 2021

Published on: 17 July, 2020

Page: [165 - 176] Pages: 12

DOI: 10.2174/1386207323666200717143540

Price: $65

Abstract

Background: Diabetes mellitus type-II is a major health problem characterized by hypoinsulinemia and insulin resistance, leading to hyperglycemia and its complications. In Unani medicine, it is known as ziyābetus. Several drugs are prescribed in Unani medicine as single and compound formulations for this disease. Most of these drugs have been studied on scientific parameters and shown significant activity in reducing the symptoms and complications of diabetes.

Objectives: Critical evaluation of Unani medicines for treating diabetes patients have been conducted. The aim of the study is to provide complete information on this subject with the action of the mechanism so that proper treatment should be done with prospective research.

Methods: Unani literature was reviewed extensively via various search engines for the herbs, shrubs used for diabetes treatment. Ten drugs were selected for the present review.

Results and Conclusion: There is convincing evidence to suggest that the selected drugs have promising actions against diabetes and its complications. In addition, none of the studies has reported any adverse effects with the drugs. Also, there is evidence to suggest that the method of usage described in Unani medicine may reduce or eliminate adverse events, if any. Further, there is a great need to do more research on making medicine more effective. Besides, the review article is useful for treating patients effectively by advancing the research.

Keywords: Ziyābetus, diabetes mellitus type-II, insulin, hyperglycemia, mechanism of action, blood sugar.

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[1]
Saxena, A.; Vikram, N.K. Role of selected Indian plants in management of type 2 diabetes: a review. J. Altern. Complement. Med., 2004, 10(2), 369-378.
[http://dx.doi.org/10.1089/107555304323062365] [PMID: 15165418]
[2]
American Diabetes Association. 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2018. Diabetes Care, 2018, 41(Suppl. 1), S13-S27.
[http://dx.doi.org/10.2337/dc18-S002] [PMID: 29222373]
[3]
Biessels, G.J.; Janssen, J. Van der berg, E. Zinman, B.; Espeland, M.A.; Mattheus, M.; Rationale and design of the CAROLINA® - cognition substudy: a randomised controlled trial on cognitive outcomes of linagliptin versus glimepiride in patients with type 2 diabetes mellitus. BMC Neurol., 2018, 18(1), 7.
[4]
Fazil, M.; Nikhat, S.; Akram, M. Diabetes: From ancient to modern era. Hamdard Med., 2012, 55(1), 27-31.
[5]
Zuhr, I. Kitab Al-Taisir, 1st ed; CCRUM: New Delhi, 1986.
[6]
Sina, I. Al-Qanoon fil Tibb; Book Printers: Lahore, 1992.
[7]
Khan, M.A. Al-Ikseer; Ash-Shifa: Faisalabad, 1996.
[8]
Waseem, A.; Siddiqui, M.K.; Siddiqui, K.M.; Khan, K.Z. Ziyabetus-Ek Tarikhi Jayeza. Jahan-e-Tibb, 2008, 9(4), 55-60.
[9]
Bulle, S.; Reddyvari, H.; Nallanchakravarthula, V.; Vaddi, D.R. therapeutic potential of Pterocarpus santalinus L.: An Update. Pharmacogn. Rev., 2016, 10(19), 43-49.
[http://dx.doi.org/10.4103/0973-7847.176575] [PMID: 27041873]
[10]
Misra, B.B.; Dey, S. Evaluation of in vivo anti-hyperglycemic and antioxidant potentials of α-santalol and sandalwood oil. Phytomedicine, 2013, 20(5), 409-416.
[http://dx.doi.org/10.1016/j.phymed.2012.12.017] [PMID: 23369343]
[11]
Kameswara Rao, B.; Giri, R.; Kesavulu, M.M.; Apparao, C. Effect of oral administration of bark extracts of Pterocarpus santalinus L. on blood glucose level in experimental animals. J. Ethnopharmacol., 2001, 74(1), 69-74.
[http://dx.doi.org/10.1016/S0378-8741(00)00344-5] [PMID: 11137350]
[12]
Kondeti, V.K.; Badri, K.R.; Maddirala, D.R.; Thur, S.K.; Fatima, S.S.; Kasetti, R.B.; Rao, C.A. Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food Chem. Toxicol., 2010, 48(5), 1281-1287.
[http://dx.doi.org/10.1016/j.fct.2010.02.023] [PMID: 20178824]
[13]
Halim, M.E.; Misra, A. The effects of the aqueous extract of Pterocarpus santalinus heartwood and vitamin E supplementation in streptozotocin-induced diabetic rats. J. Med. Plants Res., 2011, 5(3), 398-409.
[14]
Nadkarni, K.M. Indian Materia Medica; A. K. Nadkarni and Co.: India, 1926.
[15]
Jurenka, J.S. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern. Med. Rev., 2008, 13(2), 128-144.
[PMID: 18590349]
[16]
Marwat, S.K.; Khan, M.A.; Khan, M.A.; Ahmad, M.; Zafar, M.; Rehman, F. Fruit plant species mentioned in the Holy Qura’n and ahadith and their ethnomedicinal importance. Am-Euras. J. Agric. & Environ. Sci., 2009, 5(2), 284-295.
[17]
Ali, S.S. Unani Adviya Mufrada; National Council for Promotion of Urdu Language: New Delhi, 2010.
[18]
Shulman, Y.; Fainberstein, L.; Lavee, S. Pomegranate fruit development and maturation. J. Hortic. Sci., 1984, 59(2), 265-274.
[http://dx.doi.org/10.1080/00221589.1984.11515196]
[19]
Viuda-Martos, M.; Fernández-López, J.; Pérez-Álvarez, J. Pomegranate and its many functional components as related to human health: a review. Compr. Rev. Food Sci. Food Saf., 2010, 9, 635-654.
[http://dx.doi.org/10.1111/j.1541-4337.2010.00131.x]
[20]
Banihani, S.A.; Makahleh, S.M.; El-Akawi, Z.; Al-Fashtaki, R.A.; Khabour, O.F.; Gharibeh, M.Y.; Saadah, N.A.; Al-Hashimi, F.H.; Al-Khasieb, N.J. Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients. Nutr. Res., 2014, 34(10), 862-867.
[http://dx.doi.org/10.1016/j.nutres.2014.08.003] [PMID: 25223711]
[21]
Hontecillas, R.; O’Shea, M.; Einerhand, A.; Diguardo, M.; Bassaganya-Riera, J. Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. J. Am. Coll. Nutr., 2009, 28(2), 184-195.
[http://dx.doi.org/10.1080/07315724.2009.10719770] [PMID: 19828904]
[22]
Li, Y.; Qi, Y.; Huang, T.H.; Yamahara, J.; Roufogalis, B.D. Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties. Diabetes Obes. Metab., 2008, 10(1), 10-17.
[PMID: 18095947]
[23]
Makino-Wakagi, Y.; Yoshimura, Y.; Uzawa, Y.; Zaima, N.; Moriyama, T.; Kawamura, Y. Ellagic acid in pomegranate suppresses resistin secretion by a novel regulatory mechanism involving the degradation of intracellular resistin protein in adipocytes. Biochem. Biophys. Res. Commun., 2012, 417(2), 880-885.
[http://dx.doi.org/10.1016/j.bbrc.2011.12.067] [PMID: 22206671]
[24]
Bagri, P.; Ali, M.; Aeri, V.; Bhowmik, M.; Sultana, S. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem. Toxicol., 2009, 47(1), 50-54.
[http://dx.doi.org/10.1016/j.fct.2008.09.058] [PMID: 18950673]
[25]
Li, Y.; Wen, S.; Kota, B.P.; Peng, G.; Li, G.Q.; Yamahara, J.; Roufogalis, B.D. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J. Ethnopharmacol., 2005, 99(2), 239-244.
[http://dx.doi.org/10.1016/j.jep.2005.02.030] [PMID: 15894133]
[26]
Xu, K.Z.; Zhu, C.; Kim, M.S.; Yamahara, J.; Li, Y. Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. J. Ethnopharmacol., 2009, 123(2), 280-287.
[http://dx.doi.org/10.1016/j.jep.2009.03.035] [PMID: 19429373]
[27]
Meneria, J. Anti diabetic activity of leaves extract of Bambusa arundinacea. Pharm. Chem. J., 2016, 3(2), 197-200.
[28]
Sangeetha, R.; Diea, Y.K.T.; Chaitra, C.; Malvi, P.G.; Shinomol, G.K. The amazing bamboo: a review on its medicinal and pharmacological potential. Indian J. Nutrition, 2015, 2(1), 1-7.
[29]
Ahmed, D.; Sharma, M.; Mukerjee, A.; Ramteke, P.W.; Kumar, V. Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation “Qurs Tabasheer” in streptozotocin induced diabetic rats. BMC Complement. Altern. Med., 2013, 13, 10.
[http://dx.doi.org/10.1186/1472-6882-13-10] [PMID: 23305114]
[30]
Radha, T. Fruit Crops; New India Publishing Agency: New Delhi, 2007.
[31]
Khan, A. Haziq; Beeswin Sadi Publications: New Delhi, 1983.
[32]
Sharma, S.B.; Nasir, A.; Prabhu, K.M.; Murthy, P.S. Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. J. Ethnopharmacol., 2006, 104(3), 367-373.
[http://dx.doi.org/10.1016/j.jep.2005.10.033] [PMID: 16386863]
[33]
Srivastava, S.; Chandra, D. Pharmacological potentials of Syzygium cumini: a review. J. Sci. Food Agric., 2013, 93(9), 2084-2093.
[http://dx.doi.org/10.1002/jsfa.6111] [PMID: 23460190]
[34]
Sidana, S.; Singh, V.B.; Meena, B.L.; Beniwal, S.; Singh, K.; Kumar, D. Effect of Syzygium cumini (jamun) seed powder on glycemic control: A double-blind randomized controlled trial. J. Med. Soc., 2017, 31(3), 185-189.
[http://dx.doi.org/10.4103/jms.jms_62_16]
[35]
Boskabady, M.H.; Shafei, M.N.; Saberi, Z.; Amini, S. Pharmacological effects of Rosa damascena. Iran. J. Basic Med. Sci., 2011, 14(4), 295-307.
[PMID: 23493250]
[36]
Majusi, A. Kamil-us-Sana’ah; Idara Kitab-ush-Shifa: New Delhi, 2010.
[37]
Gholamhoseinian, A.; Fallah, H. Sharifi far, F. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on alpha-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine, 2009, 16(10), 935-941.
[http://dx.doi.org/10.1016/j.phymed.2009.02.020] [PMID: 19380218]
[38]
Mohammadi, A.; Fallah, H.; Gholamhosseinian, A. Antihyperglycemic effect of Rosa damascena is mediated by PPAR.γ gene expression in animal model of insulin resistance. Iran. J. Pharm. Res., 2017, 16(3), 1080-1088.
[PMID: 29201096]
[39]
Mansouri, E.; Hardani, A.; Afzalzadeh, M.R.; Amir Zargar, A.; Meamar, Z. Combined effects of retinoic acid and hydro-alcoholic extract of Rosa damascena mill on wound in diabetic rats. Iran. J. Pharm. Res., 2016, 15(2), 583-589.
[PMID: 27642329]
[40]
Hamedi, S.; Shomali, T.; Haghighat, A. Rosa damascena Mill. Essential oil has protective effect against testicular damage in diabetic rats. J. Diet. Suppl., 2017, 9, 1-7.
[PMID: 28792252]
[41]
Shabbir, A. Rhus coriaria Linn, a plant of medicinal, nutritional and industrial importance: A review. J. Anim. Plant Sci., 2012, 22(2), 505-512.
[42]
Khare, C.P. Indian Medicinal Plants. An Illustrated Dictionary; Springer Science+BusinessMedia, LLC.: New York , 2007.
[http://dx.doi.org/10.1007/978-0-387-70638-2]
[43]
Mohammadi, S.; Montasser Kouhsari, S.; Monavar Feshani, A. Antidiabetic properties of the ethanolic extract of Rhus coriaria fruits in rats. Daru, 2010, 18(4), 270-275.
[PMID: 22615627]
[44]
Ahangarpour, A.; Heidari, H.; Junghani, M.S.; Absari, R.; Khoogar, M.; Ghaedi, E. Effects of hydroalcoholic extract of Rhus coriaria seed on glucose and insulin related biomarkers, lipid profile, and hepatic enzymes in nicotinamide-streptozotocin-induced type II diabetic male mice. Res. Pharm. Sci., 2017, 12(5), 416-424.
[http://dx.doi.org/10.4103/1735-5362.213987] [PMID: 28974980]
[45]
Shidfar, F.; Rahideh, S.T.; Rajab, A.; Khandozi, N.; Hosseini, S.; Shidfar, S.; Mojab, F. The effect of sumac (Rhus coriaria L.) powder on serum glycemic status, ApoB, ApoA-I and Total antioxidant capacity in type 2 diabetic patients. Iran. J. Pharm. Res., 2014, 13(4), 1249-1255.
[PMID: 25587314]
[46]
Malviya, S.; Rawat, S.; Kharia, A.; Verma, M. Medicinal attributes of Acacia nilotica Linn. - A comprehensive review on ethnopharmacological claims. Intl. J. Pharm. Life Sci., 2011, 2(6), 830-837.
[47]
Saha, M.R.; Dey, P.; Sarkar, I.; De Sarker, D.; Haldar, B.; Chaudhuri, T.K.; Sen, A. Acacia nilotica leaf improves insulin resistance and hyperglycemia associated acute hepatic injury and nephrotoxicity by improving systemic antioxidant status in diabetic mice. J. Ethnopharmacol., 2018, 210, 275-286.
[http://dx.doi.org/10.1016/j.jep.2017.08.036] [PMID: 28859934]
[48]
Jurjani, A.H. Zakhira Khwar-zam Shahi; Munshi Nawal Kishore: Lucknow, 1903.
[49]
Mohamed, H.N.; Mustafa, S.; Fitrianto, A.; Manap, Y.A. Development of alginate-gum arabic beads for targeted delivery of protein. J. Biomol. Res. Ther., 2017, 6(2)
[50]
Bisht, S.; Kant, R.; Kumar, V. α-D-Glucosidase inhibitory activity of polysaccharide isolated from Acacia tortilis gum exudate. Int. J. Biol. Macromol., 2013, 59, 214-220.
[http://dx.doi.org/10.1016/j.ijbiomac.2013.04.057] [PMID: 23624164]
[51]
Nasir, O.; Umbach, A.T.; Rexhepaj, R.; Ackermann, T.F.; Bhandaru, M.; Ebrahim, A.; Artunc, F.; Kempe, D.S.; Puchchakayala, G.; Siraskar, B.; Föller, M.; Saeed, A.; Lang, F. Effects of gum arabic (Acacia senegal) on renal function in diabetic mice. Kidney Blood Press. Res., 2012, 35(5), 365-372.
[http://dx.doi.org/10.1159/000336359] [PMID: 22473073]
[52]
Nasir, O.; Babikar, S.; Salim, A.M. Protective effect of gum arabic supplementation for type 2 diabetes mellitus and its complications. Int. J. Multidiscipl. Curr. Res., 2016, 4, 288-294.
[53]
Malik, A. Governing grain protein concentration and Composition in wheat and barley: use of genetic and environmental factors. Ph.D Thesis. Swedish University of Agricultural Sciences: Uppsala. 2012.
[54]
Idehen, E.; Tang, Y.; Sang, S. Bioactive phytochemicals in barley. Yao Wu Shi Pin Fen Xi, 2017, 25(1), 148-161.
[http://dx.doi.org/10.1016/j.jfda.2016.08.002] [PMID: 28911532]
[55]
Gangopadhyay, N.; Rai, D.K.; Brunton, N.P.; Gallagher, E.; Hossain, M.B. Antioxidant-guided isolation and mass spectrometric identification of the major polyphenols in barley (Hordeum vulgare) grain. Food Chem., 2016, 210, 212-220.
[http://dx.doi.org/10.1016/j.foodchem.2016.04.098] [PMID: 27211640]
[56]
Aldughpassi, A.; Abdel-Aal, S.M.; Wolever, T.M. Barley cultivar, kernel composition, and processing affect the glycemic index. J. Nutr., 2012, 142(9), 1666-1671.
[http://dx.doi.org/10.3945/jn.112.161372] [PMID: 22833662]
[57]
Sawicki, C.M.; McKay, D.L.; McKeown, N.M.; Dallal, G.; Chen, C.O.; Blumberg, J.B. Phytochemical pharmacokinetics and bioactivity of oat and barley flour: a randomized crossover trial. Nutrients, 2016, 8(12), 8.
[http://dx.doi.org/10.3390/nu8120813] [PMID: 27983687]
[58]
Kim, H.; Stote, K.S.; Behall, K.M.; Spears, K.; Vinyard, B.; Conway, J.M. Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: a dose response study in obese women with increased risk for insulin resistance. Eur. J. Nutr., 2009, 48(3), 170-175.
[http://dx.doi.org/10.1007/s00394-009-0778-3] [PMID: 19205780]
[59]
Battilana, P.; Ornstein, K.; Minehira, K.; Schwarz, J.M.; Acheson, K.; Schneiter, P.; Burri, J.; Jéquier, E.; Tappy, L. Mechanisms of action of beta-glucan in postprandial glucose metabolism in healthy men. Eur. J. Clin. Nutr., 2001, 55(5), 327-333.
[http://dx.doi.org/10.1038/sj.ejcn.1601160] [PMID: 11378805]
[60]
El Khoury, D.; Cuda, C.; Luhovyy, B.L.; Anderson, G.H. Beta glucan: health benefits in obesity and metabolic syndrome. J. Nutr. Metab, 2012, 2012
[61]
Gupta, A.D.; Bansal, V.K.; Babu, V.; Maithil, N. Chemistry, antioxidant and antimicrobial potential of nutmeg (Myristica fragrans Houtt). J. Genet. Eng. Biotechnol., 2013, 11, 25-31.
[http://dx.doi.org/10.1016/j.jgeb.2012.12.001]
[62]
Lim, T.K. Edible Medicinal And Non Medicinal Plants; Springer: New York, 2012.
[63]
Redhead, J. Utilization of Tropical Foods: Sugars; Spices and Stimulants, United Nations, Food and Agriculture Organisation: Rome, 1989.
[64]
Han, K.L.; Choi, J.S.; Lee, J.Y.; Song, J.; Joe, M.K.; Jung, M.H.; Hwang, J.K. Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes, 2008, 57(3), 737-745.
[http://dx.doi.org/10.2337/db07-0972] [PMID: 18065517]
[65]
Prasad, S.N.; Muralidhara, M. Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: attenuation of behavioral impairments and biochemical perturbations. J. Neurosci. Res., 2014, 92(9), 1205-1216.
[http://dx.doi.org/10.1002/jnr.23393] [PMID: 24752916]
[66]
Yuan, Z.M.; Wang, J.; Lv, J.; Jia, T.Z. Comparing analysis of components in volatile oils of nutmeg and prepared nutmeg by GC-MS. Zhongguo Zhongyao Zazhi, 2006, 31(9), 737-739.
[PMID: 17048680]
[67]
Tan, K.H.; Nishida, R. Methyl eugenol: its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination. J. Insect Sci., 2012, 12, 56.
[http://dx.doi.org/10.1673/031.012.5601] [PMID: 22963669]
[68]
Fajemiroye, J.O.; Galdino, P.M.; De Paula, J.A.; Rocha, F.F.; Akanmu, M.A.; Vanderlinde, F.A.; Zjawiony, J.K.; Costa, E.A. Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol. Food Funct., 2014, 5(8), 1819-1828.
[http://dx.doi.org/10.1039/C4FO00109E] [PMID: 24920211]
[69]
Iram, F.; Khan, S.A.; Hussain, A. Phytochemistry and potential therapeutic actions of Boswellic acids: A mini-review. Asian Pac. J. Trop. Biomed., 2017, 7(6), 513-523.
[http://dx.doi.org/10.1016/j.apjtb.2017.05.001]
[70]
Tyler, V.M.; Premila, M.S. Ayurvedic Herbs: A Clinical Guide to the Healing Plants of Traditional Indian Medicine; Routledge: London, 2006.
[71]
Stephenson, J.; Churchill, J.M. Medical Botany; John Churchill: London, 1837.
[72]
Shehata, A.M.; Quintanilla-Fend, L.; Bettio, S.; Singh, C.B.; Ammon, H.P. Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE). Phytomedicine, 2011, 18(12), 1037-1044.
[http://dx.doi.org/10.1016/j.phymed.2011.06.035] [PMID: 21831620]
[73]
Farzaei, M.H.; Rahimi, R.; Farzaei, F.; Abdollahi, M. Traditional medicinal herbs for the management of diabetes and its complications: an evidence-based review. Int. J. Pharmacol., 2015, 11(7), 874-887.
[http://dx.doi.org/10.3923/ijp.2015.874.887]
[74]
Azemi, M.E.; Namjoyan, F.; Khodayar, M.J.; Ahmadpour, F.; Darvish Padok, A.; Panahi, M. The antioxidant capacity and anti-diabetic effect of Boswellia serrata triana and planch aqueous extract in fertile female diabetic rats and the possible effects on reproduction and histological changes in the liver and kidneys. Jundishapur J. Nat. Pharm. Prod., 2012, 7(4), 168-175.
[http://dx.doi.org/10.17795/jjnpp-6755] [PMID: 24624177]
[75]
Ahangarpour, A.; Heidari, H.; Fatemeh, R.A.; Pakmehr, M.; Shahbazian, H.; Ahmadi, I.; Mombeini, Z.; Mehrangiz, B.H. Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients. J. Diabetes Metab. Disord., 2014, 13(1), 29.
[http://dx.doi.org/10.1186/2251-6581-13-29] [PMID: 24495344]
[76]
Ur Rehman, N.; Khan, A.; Al-Harrasi, A.; Hussain, H.; Wadood, A.; Riaz, M.; Al-Abri, Z. New α-Glucosidase inhibitors from the resins of Boswellia species with structure-glucosidase activity and molecular docking studies. Bioorg. Chem., 2018, 79, 27-33.
[http://dx.doi.org/10.1016/j.bioorg.2018.04.020] [PMID: 29715636]
[77]
Ali, I. Nano anti-cancer drugs: pros and cons and future perspectives. Curr. Cancer Drug Targets, 2011, 11(2), 131-134.
[http://dx.doi.org/10.2174/156800911794328457] [PMID: 21062238]
[78]
Ali, I.; Lone, M.N.; Al-Othman, Z.A.; Al-Warthan, A.; Sanagi, M.M. Lone, M.N.; AL-Othman, Z.A.; Alwarthan, A. Heterocyclic scaffolds: Centrality in anticancer drug development. Curr. Drug Targets, 2015, 16(7), 711-734.
[http://dx.doi.org/10.2174/1389450116666150309115922] [PMID: 25751009]
[79]
Ali, I.; Saleem, K.; Wesselinova, D.; Haque, A. Synthesis, DNA binding, hemolytic and anticancer assays of curcumin I based ligands and their ruthenium (III) complexes. Med. Chem. Res., 2013, 22, 1386-1398.
[http://dx.doi.org/10.1007/s00044-012-0133-8]
[80]
Ali, I.; Aboul-Enein, H.Y.; Ghanem, A. Enantioselective toxicities and carcinogenesis. Curr. Pharm. Anal., 2005, 1, 109-125.
[http://dx.doi.org/10.2174/1573412052953328]
[81]
Saleem, K.; Wani, W.A.; Haque, A.; Lone, M.N.; Hsieh, M.F.; Jairajpuri, M.A.; Ali, I. Synthesis, DNA binding, hemolysis assays and anticancer studies of copper(II), nickel(II) and iron(III) complexes of a pyrazoline-based ligand. Future Med. Chem., 2013, 5(2), 135-146.
[http://dx.doi.org/10.4155/fmc.12.201] [PMID: 23360139]
[82]
Ali, I.; Lone, M.N.; Aboul-Enein, H.Y. Imidazoles as potential anticancer agents. MedChemComm, 2017, 8(9), 1742-1773.
[http://dx.doi.org/10.1039/C7MD00067G] [PMID: 30108886]
[83]
Ali, I.; Wani, W.A.; Saleem, K.; Haque, A. Thalidomide: A banned drug resurged into future anticancer drugs. Curr. Drug Ther., 2012, 7, 13-23.
[http://dx.doi.org/10.2174/157488512800389164]
[84]
Singh, A.; Dwivedi, S. Study of adverse drug reactions in patients with diabetes attending a tertiary care hospital in New Delhi, India. Indian J. Med. Res., 2017, 145(2), 247-249.
[PMID: 28639602]
[85]
Eurich, D.T.; McAlister, F.A.; Blackburn, D.F.; Majumdar, S.R.; Tsuyuki, R.T.; Varney, J.; Johnson, J.A. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. BMJ, 2007, 335(7618), 497.
[http://dx.doi.org/10.1136/bmj.39314.620174.80] [PMID: 17761999]
[86]
Kapoor, N.; Thomas, N. Oral antidiabetic agents: Recently available novel oral antidiabetic agents in India: A clinical review. Curr. Med. Issues., 2017, 15, 169-176.
[http://dx.doi.org/10.4103/cmi.cmi_39_17]
[87]
Shroff, G.; Shroff, R.; Gupta, R. Analysis of the regulation pathways via microarray and miRNA studies: human embryonic stem cells to treat diabetes mellitus type-II. Am. J. Stem Cells, 2018, 7(2), 48-55.
[PMID: 29938125]
[88]
Fazil, M.; Akram, M. Factors contributing to irritability in diabetes mellitus type-2 patients. Altern. Integr. Med., 2019, 8(1), 277.

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