Background: Cancer is one of the leading cause of death worldwide. Besides current therapies
and treatments to counter cancer, new alternatives are required to diminish the cell proliferation of
Methods: One of the most promissory therapy includes the use of blue scorpion venom as a specific
cytotoxic agent to kill tumoral cells, including Glioblastoma multiforme.
Objectives: We show evidence of the cytotoxic effect of blue scorpion venom in a cellular model of
Results: Our results demonstrate that 50 μg/ml of scorpion venom is capable to diminish the viability
of Glioblastoma populations.
Conclusion: It is possible that the action mechanism could be associated with a loss of membrane integrity.
Additionally, some metalloproteinases as MMP2 and MMP9 may also participate in the potential