Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not
been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all
ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential
therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective
drug delivery system. The delivery systems employing the use of polymers, such as chitosan and
pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects
and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an
increased amount of the drug to reach the target tissue or cells. In this systematic review of published
literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted
delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the
use of chitosan and pectin in colon targeted drug delivery systems.
Keywords: Colon cancer, drug carriers, carbohydrate polymers, drug delivery, chitosan, pectin.
Rights & PermissionsPrintExport