Chronic hyperglycemia is an established risk factor for the development of complications in both type 1 and
type 2 diabetes, but glycemic variability has emerged as a possible independent risk factor for diabetes complications,
possibly throughout oxidative stress. In this review we discuss methods to access glycemic variability and oxidative
stress, as well as their correlations. We also debate non-pharmacological and pharmacological strategies to achieve a
better glycemic control, not only by HbA1c target, but also with reduced glycemic fluctuations, possibly minimizing the
risk of diabetes complications.