Chalcone Derived Pyrazole Synthesis via One-pot and Two-pot Strategies

Author(s): Saba Farooq*, Zainab Ngaini

Journal Name: Current Organic Chemistry

Volume 24 , Issue 13 , 2020

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Graphical Abstract:


Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal fields. Pyrazole is stable compound that is particularly used in pharmaceutical applications (i.e., anticancer, antifungal, antiviral, antimicrobial and antioxidant) and electronic industries. This review depicted the synthesis of pyrazoles derivatives by employing chalcone derivatives as a starting material via one and two-pot strategies. The one-pot strategy is an exclusive method for chalcone cyclization and oxidation, while two-pot strategy is reported through the preparation of chalcone derivatives, i.e., pyrazoline, hydrazone and bromochalcone prior to the synthesis of pyrazole. One-pot strategy is frequently reported for pyrazole synthesis purposes due to unique, stable, reactive and well-known chalcone reactants having easy handing then two-pot strategy. This review is momentous in organic chemistry, especially synthesis related to pyrazole and drug industry.

Keywords: Pyrazole, chalcone, hydrazine, oxidation, cyclization, pyrazoline.

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Article Details

Year: 2020
Page: [1491 - 1506]
Pages: 16
DOI: 10.2174/1385272824999200714101420
Price: $65

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PDF: 33
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