Renin-angiotensin System Inhibitors and Development of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Author(s): Fereshteh Asgharzadeh, Reza Jafarzadeh-Esfehani, Seyed M. Hassanian, Gordon A. Ferns, Amir Avan*, Majid Khazaei*

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 39 , 2020


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Abstract:

Background: There are controversial results available about using angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) and the development of cancers or improvement of clinical outcomes. Studies reported that using ACEI/ARB may enhance the development of hepatocellular carcinoma (HCC) and clinical outcomes.

Objective: This meta-analysis aimed to assess the relationship between ACEI/ARB therapy and the development of HCC.

Methods: PubMed, EMBASE and the Cochrane library were reviewed to identify clinical studies investigating the association between ACEI/ARB therapy and the risk of HCC development. The pooled risk ratio (RR) with 95% confidence intervals collected for the association between using ACEIs/ARBs and HCC development.

Results: Patients with HCC benefit from the treatment with both ACEIs and ARBs (RR 0.704, 95% CI 0.526- 0.944, p = 0.019). However, only using ARBs was related to HCC risk (0.545 95% CI 0.470-0.632, P<0.0001). Moreover, the study types were significantly related to the observed effects of using both ARBs and ACEIs. Only cohort studies were significantly related to achieving better results (RR=0.513, 95% CI= 0.442-0.597, P<0.0001).

Conclusion: Despite the small number and heterogeneity of the studies evaluating the relationship between treatment with ARBs and ACEIs and the development of HCC, our meta-analysis demonstrates that they may reduce the risk of HCC.

Keywords: Angiotensin receptor blocker, angiotensin-converting enzyme inhibitor, hepatocellular carcinoma, therapy, heterogeneity, cohort studies.

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Article Details

VOLUME: 26
ISSUE: 39
Year: 2020
Published on: 10 November, 2020
Page: [5079 - 5085]
Pages: 7
DOI: 10.2174/1381612826666200713165018
Price: $65

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