Background: The medicinal plant Myrtus communis L. (Myrtle) has properties, including
anti-inflammatory and wound healing in Persian Medicine.
Objective: The objective of this study was to explore the wound healing potential of the local application
of a gel containing aqueous extract of the plant berry in streptozotocin (STZ)-induced diabetic
Methods: Seven days after diabetes establishment, full-thickness excision skin wounds were made
in normal and diabetic rats where treated groups received topical application of a gel containing
6% aqueous extract of myrtle berries for 3 weeks. The rate of wound healing and the level of epidermal
and dermal maturation in the wound tissue were determined.
Results: The results showed that after 3 and 7 days of wound injury, the gel significantly improved
wound healing by accelerating epidermal and dermal maturation in diabetic rats with no
significant effect in the control group. However, the wounds of all groups almost completely
healed after 3 weeks.
Conclusion: These results demonstrate that aqueous extract of myrtle possesses a definite wound
healing potential in diabetic conditions. The present findings may suggest the use of topical myrtle
berries aqueous extract gel 6% to treat and manage intractable diabetic wounds.