The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide,
being a rapidly spreading disease with possible severe complications for pregnant women and neonates.
There is currently no preventative therapy or specific treatment available. Within this context,
drug repositioning is a very promising approach for the discovery of new treatment compounds, since
old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to
identify promising compounds to combat this virus. The mechanism of action at the molecular level
and the structure-activity relationship of prototypes are discussed. Among the candidates identified, we
highlight sofosbuvir, chloroquine and suramin, which present a greater quantity of experimental data to
draw on for our discussion. The current treatment is palliative; therefore, this study is of paramount
importance in identifying drug candidates useful for combating ZIKV.
Keywords: Zika virus, drug repositioning, treatment, medicinal chemistry, infection disease, drug design.
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