Aims & Objective: In this work, the multicomponent reaction of aldehydes,
benzoylisothiocyanate and alkyl bromides in the presence of ammonium acetate, sodium cyanide
and a catalytic amount of KF/Clinoptilolite nanoparticles (KF/CP NPs) in the water at 100oC was
Materials and Methods: In these reactions, thiazole derivatives were produced in good to excellent
yields and short time. Also, the antioxidant activity was studied for some newly synthesized
compounds using the DPPH radical trapping and reducing of ferric ion experiments and comparing
results with the synthetic antioxidants (TBHQ and BHT).
Results: As a result, the compounds 4b showed excellent DPPH radical trapping and reducing the
strength of ferric ion. These compounds have biological potential because of the thiazole core. For
this reason, the antimicrobial activity of some synthesized compounds was studied by employing
the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria.
Conclusion: The results of the disk diffusion test showed that these compounds prevented bacterial growth.