Title:The Role of STAT3 Signaling in Different Types of Cancers: A Comprehensive Review
VOLUME: 16 ISSUE: 3
Author(s):Kaviarasan Lakshmanan, Gowramma Byran*, Sravanthi Bandlamudi and Praveen Thaggikuppe Krishnamurthy
Affiliation:Department of Pharmaceutical Chemistry, JSS College of Pharmacy, (JSS Academy of Higher Education and Research) Ooty, Nilgiris-643001 Tamilnadu, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, (JSS Academy of Higher Education and Research) Ooty, Nilgiris-643001 Tamilnadu, Department of Pharmacology, JSS College of Pharmacy, (JSS Academy of Higher Education and Research) Ooty, Tamilnadu, Department of Pharmacology, JSS College of Pharmacy, (JSS Academy of Higher Education and Research) Ooty, Tamilnadu
Keywords:Cancer, gene transcription, hyperactivation, phosphorylation, solid tumor, STAT3.
Abstract:Signal transducer and activator of transcription (STAT3) is an important transcription factor
capable of mediating or even driving cancer progression through hyperactivation or gain-offunction
mutations. It plays a key role in regulating host immune and inflammatory responses and in
the pathogenesis of many cancers. However, compelling evidence suggests that STAT3 is constitutively
activated in many cancers and plays a vital role in tumor growth and metastasis. Hyperactive
STAT3 is also implicated in various hematopoietic and solid malignancies, such as chronic and acute
myeloid leukemia, melanoma or prostate cancer. The classical understanding of STAT functions is
linked to their phosphorylated parallel dimer conformation, in which they induce gene transcription.
In this review, we discuss the functions and the roles of STAT3 signal in various types of cancers.
