Abstract
Signal transducer and activator of transcription (STAT3) is an important transcription factor capable of mediating or even driving cancer progression through hyperactivation or gain-offunction mutations. It plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. However, compelling evidence suggests that STAT3 is constitutively activated in many cancers and plays a vital role in tumor growth and metastasis. Hyperactive STAT3 is also implicated in various hematopoietic and solid malignancies, such as chronic and acute myeloid leukemia, melanoma or prostate cancer. The classical understanding of STAT functions is linked to their phosphorylated parallel dimer conformation, in which they induce gene transcription. In this review, we discuss the functions and the roles of STAT3 signal in various types of cancers.
Keywords: Cancer, gene transcription, hyperactivation, phosphorylation, solid tumor, STAT3.
Current Enzyme Inhibition
Title:The Role of STAT3 Signaling in Different Types of Cancers: A Comprehensive Review
Volume: 16 Issue: 3
Author(s): Kaviarasan Lakshmanan, Gowramma Byran*, Sravanthi Bandlamudi and Praveen Thaggikuppe Krishnamurthy
Affiliation:
- Department of Pharmaceutical Chemistry, JSS College of Pharmacy, (JSS Academy of Higher Education and Research) Ooty, Nilgiris-643001 Tamilnadu,India
Keywords: Cancer, gene transcription, hyperactivation, phosphorylation, solid tumor, STAT3.
Abstract: Signal transducer and activator of transcription (STAT3) is an important transcription factor capable of mediating or even driving cancer progression through hyperactivation or gain-offunction mutations. It plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. However, compelling evidence suggests that STAT3 is constitutively activated in many cancers and plays a vital role in tumor growth and metastasis. Hyperactive STAT3 is also implicated in various hematopoietic and solid malignancies, such as chronic and acute myeloid leukemia, melanoma or prostate cancer. The classical understanding of STAT functions is linked to their phosphorylated parallel dimer conformation, in which they induce gene transcription. In this review, we discuss the functions and the roles of STAT3 signal in various types of cancers.
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Cite this article as:
Lakshmanan Kaviarasan, Byran Gowramma *, Bandlamudi Sravanthi and Krishnamurthy Thaggikuppe Praveen , The Role of STAT3 Signaling in Different Types of Cancers: A Comprehensive Review, Current Enzyme Inhibition 2020; 16 (3) . https://dx.doi.org/10.2174/1573408016999200708160300
DOI https://dx.doi.org/10.2174/1573408016999200708160300 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
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