Background: The progressive treatment of cancer using disulfide bond-based therapeutics offers improvement
in therapeutic potency of active, reduction in adverse events, prolongation of drug release pattern and
on-site action by interacting with neoplastic cell microenvironment.
Objective: The objective of this article is to highlight the research carried out on disulfide bond-based drug delivery
systems as a potential candidate for cancer treatment.
Methods: The article provides an overview of the importance of disulfide bonds in cancer treatment in terms of
their properties, mechanism of formation/fragmentation and applications. Properties of disulfide bonds, such as
pKa, entropy, and dihedral angle contribute to the structural stability of the bonds in a nanotherapeutic system,
while their formation and fragmentation are attributed to the presence of a high concentration of GSH in cancer
cells. The article further focuses on various drug delivery systems like dendrimers, liposomes, micelles, etc. involving
disulfide cross-linked polymers for the preparation of redox-responsive drug delivery systems.
Results: The use of nanotechnology with disulfide bond creates an anticancer drug delivery system with higher
target specificity, improved bioavailability, and good therapeutic efficacy.
Conclusion: In the near future, the combination of DSB with active, cellular material, stem cell and biological
fluid will be considered as a new thrust area for research in healthcare.