Disulfide Bond-Responsive Nanotherapeutic Systems for the Effective Payload in Cancer Therapy

Author(s): Pravin Shende*, Gauraja Deshpande

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 41 , 2020


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Abstract:

Background: The progressive treatment of cancer using disulfide bond-based therapeutics offers improvement in therapeutic potency of active, reduction in adverse events, prolongation of drug release pattern and on-site action by interacting with neoplastic cell microenvironment.

Objective: The objective of this article is to highlight the research carried out on disulfide bond-based drug delivery systems as a potential candidate for cancer treatment.

Methods: The article provides an overview of the importance of disulfide bonds in cancer treatment in terms of their properties, mechanism of formation/fragmentation and applications. Properties of disulfide bonds, such as pKa, entropy, and dihedral angle contribute to the structural stability of the bonds in a nanotherapeutic system, while their formation and fragmentation are attributed to the presence of a high concentration of GSH in cancer cells. The article further focuses on various drug delivery systems like dendrimers, liposomes, micelles, etc. involving disulfide cross-linked polymers for the preparation of redox-responsive drug delivery systems.

Results: The use of nanotechnology with disulfide bond creates an anticancer drug delivery system with higher target specificity, improved bioavailability, and good therapeutic efficacy.

Conclusion: In the near future, the combination of DSB with active, cellular material, stem cell and biological fluid will be considered as a new thrust area for research in healthcare.

Keywords: Disulfide bonds, glutathione, tumor tissue, reduction responsiveness, cross-linked polymers, redox-responsive drug delivery systems.

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Article Details

VOLUME: 26
ISSUE: 41
Year: 2020
Published on: 12 December, 2020
Page: [5353 - 5361]
Pages: 9
DOI: 10.2174/1381612826666200707131006
Price: $65

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