Comparison of Helicobacter pylori Detection Methods: It’s Association with Leukocytosis and Monocytosis

Author(s): Monireh Rahimkhani*, Alireza Mordadi, Kiana Kazemian, Hourieh Khalili

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Volume 20 , Issue 6 , 2020

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Background: Helicobacter pylori is a slow-growing micro-aerophilic gram-negative organism found in the stomach and duodenum. It is also associated with a number of stomach-duodenal diseases.

Material and Methods: There are invasive and non-invasive methods to detect Helicobacter pylori infections. In a 13-months period, 101 patients with clinical signs of infection confirmed by biopsy and Rapid Urease test as well as a culture were included in this study.

Results: There were significant correlations between breath urease test, anti-Helicobacter pylori serum IgG and IgA as well as fecal Helicobacter pylori Ag with the gold-standard method, (P=0.001) Moreover, there was a significant correlation between Monocytosis (P= 0.05) and goldstandard method.

Conclusion: Based on studies conducted on patients with Helicobacter pylori infection, noninvasive diagnostics methods can be useful in the diagnosis of Helicobacter infections rather than evaluating anti-Helicobacter pylori serum IgM and also increased blood monocytes could be a reliable confirmation for detection. Furthermore, Monocytosis must be considered as a Helicobacter pylori infection at the first step in an area with a high infected percentage.

Keywords: Helicobacter pylori, diagnosis methods, monocytosis, infection, Leukocytosis , gram-negative.

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Article Details

Year: 2020
Published on: 20 January, 2021
Page: [920 - 924]
Pages: 5
DOI: 10.2174/1871526520666200707113955
Price: $65

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