Background: Nowadays, the biological properties and anticancer activities of platinum-based drugs
and metal coordination complexes have been receiving particular attention. These compounds have revealed
clinical potential in cancer chemotherapy.
Objective: In this research, two binuclear platinum complexes including [Pt2Cl2(bhq)2(μ-dppm)] (1) and [(p-
MeC6H4)(bhq) Pt(μ-dppm)Pt(bhq)(CF3CO2)] (2) with bhq: benzo[h] quinolone and dppm: bis(diphenylphosphino)
methane have been synthesized and evaluated for their anticancer activity against A2780 and A2780/RCIS cancer
Methods: The DNA binding and interaction of AMP/GMP nucleotide with these complexes were explored by
several experimental and theoretical methods, including UV-Visible, fluorescence spectroscopic techniques and
docking analysis. These complexes have demonstrated significant anticancer properties against cisplatinsensitive
(A2780) and cisplatin-resistant (A2780/RCIS) human ovarian cancer cell lines.
Results: The obtained results indicated that these complexes interact with DNA. Additionally, the fluorescence
emission measurements indicated that the platinum complexes binding with DNA structure occurs through nonintercalative
interaction. The molecular docking assessments have also revealed the binding of these platinum
complexes through DNA grooves. Moreover, the results have indicated that complex 1 exhibited more anticancer
activity than complex 2.
Conclusion: The results of the DNA binding with these platinum complexes confirmed their potential antitumor
properties. The substitution of -C6H4CH3 and -CO2CF3 groups in complex 2 with two chlorine atoms in complex 1
acquired the significant improvement of the anticancer activity against the cancer cell.